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PhD Position: ― University of British Columbia (Vancouver, Canada)

Overview

Our lab at UBC (Department of Medicine / School of Biomedical Engineering, located at the Centre for Heart Lung Innovation at St. Paul’s Hospital) seeks a motivated PhD student to develop and apply methods for precision in silico modeling of human cardiac disease. The successful candidate will work at the interface of wet-lab genomics and computational analysis within a collaborative, translational research environment. We have several areas of potential focus including multi-omics, high-throughput video microscopy, electrophysiological simulation models, and the integration/analysis of these.

Responsibilities

Analyses multi-omics data, including transcriptomics, single-cell transcriptomics, proteomics, metabolomics, and/or spatial transcriptomics data, using reproducible workflows.

Develops database of experimental data/metadata to enable integration of datasets with each other and with related in vitro or clinical measurements.

Interprets results, prepares manuscripts, presents at conferences, and contributes to grant applications.

Develops and maintains reproducible workflows and supports others in their use.

Qualifications (Required)

Bachelor’s/Master’s in computer science, statistics, computational biology, genomics, biomedical engineering, or related fields.

Demonstrated experience with large and complex datasets.

Demonstrated proficiency in at least one of: Bioconductor, Tidymodels, the Python Scientific stack, SciKitLearn, PyTorch, openCARP, pharmacokinetics modeling, or full-stack development.

Familiar with containerization (Docker/Singularity), workflow managers (Nextflow, Snakemake, Airflow or similar) and cloud computing.

Solid grounding in statistics, experimental design, and reproducible research.

Assets (Preferred)

Wet-lab biology experience including understanding of genomics methods and/or bioengineering.

Experience with cardiovascular or iPSC-derived model biology.

Experience with multi-modal integration and machine learning.

Funding & Start Date

Competitive stipend per UBC guidelines; start date flexible in 2025/2026.

How to Apply

Email 1) CV, 2) brief statement of research interests (≤1 page), 3) transcripts (unofficial ok), and 4) contact info for 23 referees. Please use the subject line: PhD Application―Computational Biology.

Equity, Diversity & Inclusion

We welcome applications from all qualified candidates and are committed to an inclusive, supportive research environment. International applicants are encouraged to apply and must meet UBC Graduate Program requirements.v